Atopic dermatitis (Eczema) is an inflammatory, chronically relapsing, non-contagious and extremely pruritic skin disease. The discussion about pathogenesis of this disease is mirrored by the different names that it has been given ("prurigo Besnier," "neurodermitis," "endogenous eczema," etc.)
Lactofiltrum’s development is derived from our understanding of the gut biota and the its role on the gastrointestinal integrity and permeability, limiting the interaction of allergens, pathogenic micro-organisms and toxicants, with the endothelium.
Lactofiltrum is a combination of an enterosorbent, Lignin hydrolysed and a prebiotic disaccharide, Lactulose. Due to its composition (indigestible dietary fibres) Lactofiltrum tablets are pharmacologically inert, passing though the upper gastrointestinal tract and reach colon unchanged.
The bifidogenic activity of Lactulose: Lactofiltrum tablets stimulate growth and activity of the intestinal normal flora, providing by that positive environment for immunostimulatory function of normal flora; that leads to suppression of bacterial translocation mechanisms, decrease the number of Еnterobacteriaceae, and reduction of intraluminal and systemic endotoxin development.
Lignin hydrolysed, having a high sorption capacity, binds and removes allergens, mediators, products of allergic reaction, metabolites, toxins, and active peroxide compounds from intestine.
Lactulose also stimulates synthesis of short-chain fatty acids by Bifidobacteria and Lactobacilli. Short-chain fatty acids can influence immune modulation, due to their ability to increase the production of IL-10 and TGF-β1 which, being anti-inflammatory cytokines, play a key role in reduction of allergen-induced response.